Reference of 6738-23-4, These common heterocyclic compound, 6738-23-4, name is 2,4-Dimethylanisole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Example 32 2-Methoxy-3,5-dimethylbenzaldehyde To a solution of 1-methoxy-2,4-dimethylbenzene (8.00 g, 58.7 mmol) and 1,1-dichloromethyl methyl ether (7.40 g, 64.7 mmol) in methylene chloride (30 mL) was added titanium tetrachloride (20.0 g, 105 mmol) at 0 C. and the mixture was stirred at that temperature for 20 minutes. This reaction mixture was poured into iced water and the organic layer was taken, washed with saturated aqueous sodium hydrogen carbonate solution, dried over MgSO4, and filtered. The filtrate was concentrated under reduced pressure to provide 9.40 g of the title compound. Yield 98%. Oil. 1H-NMR (CDCl3) delta: 2.306 (3H, s), 2.312 (3H, s), 3.85 (3H, s), 7.25-7.27 (1H, m), 7.48 (1H, d, J=1.8 Hz), 10.3 (1H, s).
Statistics shows that 2,4-Dimethylanisole is playing an increasingly important role. we look forward to future research findings about 6738-23-4.
Reference:
Patent; Takeda Chemical Industries, Ltd.; US6248766; (2001); B1;,
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