Synthetic Route of 103291-07-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 103291-07-2, name is 4-Bromo-1-fluoro-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 4-bromo-1-fluoro-2-methoxybenzene (Aldrich) (20 g, 97.5 mmol), methyl methacrylate (Aldrich) (24 g, 244 mmol) in DMF (150 ml) was added Pd(OAc)2 (2.2 g, 9.7 mmol), Bu3N (45 g, 244 mmol), TOP (8.9 g, 29 mmol). The resulting mixture was degassed and charged with N2 three times, and then stirred at 100 C. for 5 hrs. After cooling down, the mixture was filtered over celite. The filtration was evaporated under reduced pressure to the residue, which was treated with water and ethyl acetate. The separated organic layer was washed with brine (*3), dried over anhydrous Na2SO4 and filtered. The filtration was concentrated under reduced pressure to give the crude product, which was purified by column chromatography on silica gel eluting with 0?10% ethyl acetate in hexanes to afford the title compound as a yellow solid. LC-MS: Rt=1.48 mins; MS m/z [M+H]+ 225.0; Method 5-95AB 1.5minLC_v003
The chemical industry reduces the impact on the environment during synthesis 4-Bromo-1-fluoro-2-methoxybenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; NOVARTIS AG; CHEN, Shuhui; HE, Haiyang; LAGU, Bharat; QIN, Hua; WU, Chengde; XIAO, Yisong; US2015/183802; (2015); A1;,
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