Adding a certain compound to certain chemical reactions, such as: 16728-64-6, name is 3-(Benzyloxy)propan-1-amine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16728-64-6, Computed Properties of C10H15NO
Step 3 3-(3-(benzyloxy)propyl)-6-methoxyquinazoline-2,4(1H,3H)-dione To a solution of 6-methoxy-1H-benzo[d][1,3]oxazine-2,4-dione (0.92 g, 4.77 mmol) in THF (10 mL) was added 3-(benzyloxy)propan-l-amine (0.94 g, 5.72 mmol) and then TEA (0.97 g, 9.54 mmol) dropwise. The reaction was heated at 80C for lh, cooled to RT and diluted with EA (20 mL) and water (10 mL). The organic layer was dried over Na2SC>4 and concentrated to a brown oil. The oil was dissolved in THF (10 mL), cooled to 0C, then triphosgene (565 mg, 1.91 mmol) was added. The reaction was stirred at RT for 30 min then TEA (389 mg, 3.82 mmol) was added. The reaction was stirred at RT for 2h and filtered. The filtrate was concentrated and dried to give 3-(3-(benzyloxy)propyl)-6-methoxyquinazoline-2,4(1H,3H)-dione (1.3 g, 80% yield) as a brown oil. LCMS: MH 341 and TR = 1.456 min. Used without further purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Benzyloxy)propan-1-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; HYDRA BIOSCIENCES, INC.; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; CHENARD, Bertrand L.; GALLASCHUN, Randall J.; (73 pag.)WO2016/23826; (2016); A1;,
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