Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39538-68-6, name is 2-Methoxy-4-methylaniline, A new synthetic method of this compound is introduced below., Computed Properties of C8H11NO
General procedure: In a threaded ACE glass pressure tube with a sealed Teflon screw cap equipped with a magnetic stirring bar, a mixture of 11a (0.200 g, 1.65 mmol), 12a (0.185 g, 1.65 mmol), p-TsOH (0.028 g, 0.16 mmol), and MS 4A (0.20 g) in toluene (10 mL) was stirred and heated at 130 C for 4.5 h under microwave irradiation (100 W). The solvent was removed under vacuum and the residue purified by column chromatography (silica gel, hexane-EtOAc, 98:2) to give 7a (0.32 g, 91%) as a brownishoil; Rf = 0.75 (hexane-EtOAc, 7:3).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Hernandez-Benitez, R. Israel; Zarate-Zarate, Daniel; Delgado, Francisco; Tamariz, Joaquin; Synthesis; vol. 49; 18; (2017); p. 4357 – 4371;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem