Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 450-88-4, name is 1-Bromo-4-fluoro-2-methoxybenzene, A new synthetic method of this compound is introduced below., Quality Control of 1-Bromo-4-fluoro-2-methoxybenzene
10504] Under a nitrogen atmosphere, into a reaction vessel equipped with a dropping flannel were added 1.00 g of 2-bromo-5-fluoroanisole and 20 mE of tetrahydrofuran. The resultant solution was cooled down to -78 C., then, 3.0 mE of n-butyllithium (1.62 Mlhexane solution) was dropped. The resultant mixture was stirred at the same temperature for 3 hours, then, a solution obtained by dissolving 1.00 g of chlorodicyclopentylphosphine in 13 ml of tetrahydroffiran was dropped at -78 C. The resultant mixture was stirred at room temperature for 3 hours. The resultant reaction mixture was concentrated, to obtain 1.75 g of a mixture in the form of viscous liquid containing dicyclopentyl(4-fluoro-2-methox- yphenyl)phosphine.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Sumitomo Chemical Company, Limited; ODA, Seiji; KAMIKAWA, Takashi; US2015/322101; (2015); A1;,
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