Application of 7025-06-1,Some common heterocyclic compound, 7025-06-1, name is 1-Bromo-2-phenoxybenzene, molecular formula is C12H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of l-(3,4-dihydroisoquinolin-2(lH)-yl)-3-(3-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenoxy)propan-2-ol (200 mg, 0.489 mmol), l-bromo-2-phenoxybenzene (120 mg, 0.489 mmol), Pd(dppf)Cl2 (36 mg, 0.049 mmol), K2C03 (202 mg, 1.47 mmol) in H20-dioxane (1 mL/ 3 mL) was stirred at 100°C under microwave heating for 15 min. The solvent was removed and the crude product purified by prep-HPLC to afford the title compound as the formate salt (33 mg, 15percent). 1H NMR (400 MHz, MeOD): delta 8.46 (s, 1H), 7.49 -7.22 (m, 9H), 7.17-7.11 (m, 3H), 7.04 – 6.98 (m, 2H), 6.92 – 6.90 (m, 1H), 6.87- 6.84 (m, 1H), 4.43- 4.37 (m, 1H), 4.28 (s, 2H), 3.98 (d, J = 5.2 Hz, 2H), 3.41 (t, J = 6.4 Hz, 2H), 3.25-3.13 (m, 4H)ppm; ESI-MS (m/z): 452.3 [M+l] +.
The synthetic route of 7025-06-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EPIZYME, INC.; DUNCAN, Kenneth, W.; CHESWORTH, Richard; MUNCHHOF, Michael, John; JIN, Lei; WO2014/100695; (2014); A1;,
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