In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2-Bromo-1,1-dimethoxyethane
As described by Doel et al.,13 a solution of adenine or thymine (1 equiv) and K2CO3 (1 equiv) in DMF (10 mL) was stirred at 100 C in the presence of 2-bromo-1,1-dimethoxyethane (1.1 equiv). After 24 h, the reaction was filtered and the solvent removed under reduced pressure. The crude mixture was purified by column chromatography in silica gel with MeOH: CH2Cl2 or EtOAc: hexane as mobile phase. Corresponding 9-(2,2-dimethoxyethyl)-adenine and 1-(2,2-dimethoxyethyl)-thymine were obtained in 61% and 38% isolated yields respectively. Both acetals were completely hydrolyzed after 1 h stirring in HCl 1 N at 90 C, to yield the corresponding aldehydes.20
The synthetic route of 7252-83-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Palazzolo, Martin A.; Perez-Sanchez, Maria; Dominguez De Maria, Pablo; Iribarren, Adolfo M.; Lewkowicz, Elizabeth S.; Tetrahedron Letters; vol. 53; 50; (2012); p. 6797 – 6800,4;,
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