Synthetic Route of 10103-06-7, A common heterocyclic compound, 10103-06-7, name is 2,3-Dimethoxynaphthalene, molecular formula is C12H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(a) 1-(6,7-Dimethoxy-naphthalen-2-yl)-2-methyl-propan-1-one The solution of 2,3-dimethoxynaphthalene (16.5 g), isobutyroylchloride (12.5 g) and aluminum chloride (15.7 g) in methylene chloride (200 ml) was stirred at ambient temperature overnight. The solution was then washed with saturated sodium bicarbonate and water, dried with sodium sulfate and evaporated. Finally the crude product was triturated with ether. Yield: 13.5 g, melting point 103-105 C. 1H-NMR (DMSO-d6): 8.51 (s,1H), 7.83 (s,2H), 7.53 (s,1H), 7.39 (s,1H), (s,3H), 3.91 (s,3H), 3.76-3.80 (m,1H), 1.16 (d,6H, J=8 Hz).
The synthetic route of 10103-06-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Baeckstroem, Reijo; Pystynen, Jarmo; Lotta, Timo; Ovaska, Martti; Taskinen, Jyrki; US2004/34011; (2004); A1;,
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