Related Products of 6851-80-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6851-80-5, name is 1-(2-Methoxyphenyl)-N-methylmethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: The mixture of secondary amine (1.01 mmol) and paraformaldehyde(1.01 mmol) in ethanol (3 mL) was refluxed for 1 h,until paraformaldehyde was dissolved. Then compound 5 or 6(100 mg, 0.34 mmol) was added in one portion. The reactionmixture was refluxed for 24e48 h. Ethanol was removed underreduced pressure. The residue was diluted with water and acidifiedwith an aqueous solution of hydrochloric acid (10%). The aqueousphase was washed with CH2Cl2, and then basified with saturatedNaHCO3 solution. The alkaline aqueous phase was again extractedwith CH2Cl2. The combined organic phase washed with brine, driedover Na2SO4, filtered and concentrated under reduced pressure toafford the corresponding crude aurone Mannich base derivatives.Additionally, compounds 8a-b and the corresponding 9a-b wereobtained in one pot.
The synthetic route of 1-(2-Methoxyphenyl)-N-methylmethanamine has been constantly updated, and we look forward to future research findings.
Reference:
Article; Li, Yan; Qiang, Xiaoming; Luo, Li; Yang, Xia; Xiao, Ganyuan; Liu, Qi; Ai, Jiachen; Tan, Zhenghuai; Deng, Yong; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 762 – 775;,
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