These common heterocyclic compound, 93919-56-3, name is (4-(Trifluoromethoxy)phenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H8F3NO
General procedure: To a solution of 3a-h (11.4mmol) in acetic acid (4mL) was added triethyl orthoformate (2.53g, 17.1mmol) and sodium azide (0.96g, 14.8mmol). The reaction solution was heated to 80C and reacted for 8h. After the reaction was completed, it was quenched with 5%Na2CO3 aqueous solution (30mL), and extracted with EtOAc (30mL x 2). The combined organic layers were dried with Na2SO4, filtered and concentrated. The residue was purified by column chromatography on silica gel using EtOAc/petroleum ether as eluent to give 4a-h.
The synthetic route of (4-(Trifluoromethoxy)phenyl)methanamine has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yang, Hao; Ouyang, Yifan; Ma, Hao; Cong, Hui; Zhuang, Chunlin; Lok, Wun-Taai; Wang, Zhe; Zhu, Xuanli; Sun, Yutong; Hong, Wei; Wang, Hao; Bioorganic and Medicinal Chemistry Letters; vol. 27; 20; (2017); p. 4635 – 4642;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem