Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7664-66-6, name is 4-Isopropoxyaniline, A new synthetic method of this compound is introduced below., name: 4-Isopropoxyaniline
A mixture of 4-bromo-2-fluoro-l-nitrobenzene (0.39, 1.36 mmol), 4-(propan-2-yloxy)aniline (0.229,1 .43 mmol) and K2C03 (0.38 g, 2.73 mmol) in DMF (3 mL) was stirred at 90 C for 5h. Then thereaction mixture was diluted with EtOAc and washed with 5% aq. LiCI solution. The organic phasewas dried over Na2504, filtered, and concentrated in vacuo. The residue was purified by SiC2 columnchromatography (hexanes I EtOAc from 30:1 to 20:1) to give 0.43g (90%) of the product as orangesolid.1H NMR (500 MHz, CDCI3) O 9.37 (5, 1H), 8.04 (d, 1H), 7.12-7.17 (m, 3H), 6.93-6.97 (m, 2H), 6.81 (dd, 1H), 4.56 (sep, 1H), 1.36 (d, 6H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ARISAN THERAPEUTICS INC.; PLEWE, Michael; BROWN, Eric; GANTLA, Vidyasagar; HENKEL, Gregory; MCCORMACK, Kenneth; SOKOLOVA, Nadzeda V.; SHIN, Young-Jun; (147 pag.)WO2018/13430; (2018); A2;,
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