The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole( cas:73590-85-9 ) is researched.Product Details of 73590-85-9.Che, Guoyong; Xiang, Jing; Tian, Tian; Huang, Qingfei; Cun, Linfeng; Liao, Jian; Wang, Qiwei; Zhu, Jin; Deng, Jingen published the article 《Catalytic asymmetric oxidation of 1H-benzimidazolyl pyridinylmethyl sulfides with cumene hydroperoxide catalyzed by a titanium complex with (S,S)-N,N’-dibenzyl tartramide ligand》 about this compound( cas:73590-85-9 ) in Tetrahedron: Asymmetry. Keywords: asym oxidation benzimidazolyl pyridinylmethyl sulfide titanium tartramide catalyst; esomeprazole lansoprazole rabeprazole pantoprazole asym synthesis. Let’s learn more about this compound (cas:73590-85-9).
A chiral titanium complex, formed in situ from Ti(Oi-Pr)4, (S,S)-N,N’-dibenzyl tartramide, and water was found to serve as an efficient catalyst for the asym. oxidations of 1H-benzimidazolyl pyridinylmethyl sulfides with cumene hydroperoxide (CHP) in the absence of a base. Several proton pump inhibitors (PPIs), such as esomeprazole, lansoprazole, rabeprazole, and pantoprazole were obtained in high yield (up to 92%) and excellent enantiomeric excess (up to 96%).
There is still a lot of research devoted to this compound(SMILES：CC1=CN=C(CSC2=NC3=CC(OC)=CC=C3N2)C(C)=C1OC)Product Details of 73590-85-9, and with the development of science, more effects of this compound(73590-85-9) can be discovered.
Reference:
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Ether | (C2H5)2O – PubChem