The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole( cas:73590-85-9 ) is researched.COA of Formula: C17H19N3O2S.Cotton, H.; Elebring, T.; Larsson, M.; Li, L.; Sorensen, H.; von Unge, S. published the article 《Asymmetric synthesis of esomeprazole》 about this compound( cas:73590-85-9 ) in Tetrahedron: Asymmetry. Keywords: esomeprazole asym synthesis. Let’s learn more about this compound (cas:73590-85-9).
A highly efficient synthesis of esomeprazole – the (S)-enantiomer of omeprazole – via asym. oxidation of prochiral sulfide I is described. The asym. oxidation was achieved by titanium-mediated oxidation with cumene hydroperoxide (CHP) in the presence of (S,S)-diethyl tartrate [(S,S)-DET]. The enantioselectivity was provided by preparing the titanium complex in the presence of I at an elevated temperature and/or during a prolonged preparation time and by performing the oxidation of I in the presence of an amine. An enantioselectivity of >94% ee was obtained using this method.
There is still a lot of research devoted to this compound(SMILES：CC1=CN=C(CSC2=NC3=CC(OC)=CC=C3N2)C(C)=C1OC)COA of Formula: C17H19N3O2S, and with the development of science, more effects of this compound(73590-85-9) can be discovered.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem