The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine(SMILESS: NC1=CC(C2=CC=CS2)=NN1C,cas:118430-78-7) is researched.SDS of cas: 73590-85-9. The article 《Identification of ring-fused pyrazolo pyridin-2-ones as novel poly(ADP-ribose)polymerase-1 inhibitors》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:118430-78-7).
A novel class of PARP-1 inhibitors was identified containing a non-aromatic heterocycle or carbocycle fused to a pyrazolo pyridin-2-one. Compounds displayed low nanomolar binding activity in the PARP-1 binding assay and submicromolar activity in a cell based chemosensitization assay.
I hope my short article helps more people learn about this compound(1-Methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine)SDS of cas: 118430-78-7. Apart from the compound(118430-78-7), you can read my other articles to know other related compounds.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem