The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine( cas:118430-78-7 ) is researched.Name: 1-Methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine.Norman, Rebecca E.; Perkins, Michael V.; Liepa, Andris J.; Francis, Craig L. published the article 《N,N-Dialkyl-N’-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. Part XII.* Synthesis and Reactivity of the Pyrazolo[3,4-e][1,2,4]thiadiazine Ring System》 about this compound( cas:118430-78-7 ) in Australian Journal of Chemistry. Keywords: pyrimidothiadiazine preparation; pyrazolothiadiazine preparation; dialkylchlorosulfonyl chloroformamidine aminopyrazole dinucleophilic substitution methylation alkylation. Let’s learn more about this compound (cas:118430-78-7).
N,N-Dialkyl-N’-chlorosulfonyl chloroformamidines 1 reacted regioselectively with 1-substituted 5-aminopyrazoles 2 via a 1,3-CCN dinucleophilic substitution to afford pyrazolo[3,4-e][1,2,4]thiadiazines 3 e. g., I, as the sole isolated products. Compounds 3, representatives of a very rare ring system, were shown to possess three nucleophilic sites at N2, N4, and N6. Methylation occurred at all three sites. Alkylation with benzylic halides occurred preferentially at N2, but some also occurred at N4, and at C7a. Alkylation with Et bromoacetate occurred at both N4 and N6, but the latter derivatives underwent a pyrazole ring expansion to afford pyrimido[4,5-e][1,2,4]thiadiazine derivs, e. g., II. Compounds 3 were unreactive towards various acylating agents.
In addition to the literature in the link below, there is a lot of literature about this compound(1-Methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine)Name: 1-Methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine, illustrating the importance and wide applicability of this compound(118430-78-7).
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem