Simple exploration of 118430-78-7

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemical & Pharmaceutical Bulletin called Discovery of new orally active phosphodiesterase (PDE4) inhibitors, Author is Ochiai, Hiroshi; Ishida, Akiharu; Ohtani, Tazumi; Kusumi, Kensuke; Kishikawa, Katuya; Yamamoto, Susumu; Takeda, Hiroshi; Obata, Takaaki; Nakai, Hisao; Toda, Masaaki, which mentions a compound: 118430-78-7, SMILESS is NC1=CC(C2=CC=CS2)=NN1C, Molecular C8H9N3S, Recommanded Product: 1-Methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine.

A series of 4-anilinopyrazolopyridine derivatives were synthesized and biol. evaluated as inhibitors of phosphodiesterase (PDE4). Chem. modification of 3, a structurally new chem. lead that was found in our inhouse library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chem. lead 5 are presented. Structure-activity relationship data, pharmacol. evaluation, and the subtype selectivity study are also presented.

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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem