Jana, Anupam; Zielinski, Grzegorz Krzysztof; Czarnocka-Sniadala, Sylwia; Grudzien, Krzysztof; Podwysocka, Dominika; Szulc, Marcin; Kajetanowicz, Anna; Grela, Karol published the artcile< Synthesis of Substituted β-Functionalised Styrenes by Microwave-Assisted Olefin Cross-Metathesis and Scalable Synthesis of Apremilast>, HPLC of Formula: 608141-42-0, the main research area is Apremilast scalable synthesis; styryl sulfone diastereoselective preparation; styrene diastereoselective cross metathesis vinyl sulfone microwave irradiation; allylbenzene isomerization deuteration cross metathesis vinyl sulfone.
Preparation of diversely substituted β-functionalized styrenes R1CH:CHR2 (R1 = Ph, 4-BrC6H4, 3-EtO-4-MeOC6H3, etc.; R2 = MeSO2, Et2NSO2, CHO, EtO2C, etc.) by microwave-assisted olefin cross-metathesis of styrenes R1CH:CH2 with functionalized terminal alkenes R2CH:CH2 is described. This method can be also employed in the synthesis of β-deuterated α,β-unsaturated sulfones from inexpensive allylbenzenes though unprecedented one-pot isomerization/deuteration/cross-metathesis sequence. One of such obtained cross-metathesis products has been utilized in a new scalable synthesis of Apremilast, a potent and orally active phosphodiesterase 4 and tumor necrosis factor-α inhibitor. The same strategy was used in synthesis of ent-Apremilast.
ChemCatChem published new progress about Cross-metathesis (stereoselective). 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, HPLC of Formula: 608141-42-0.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem