Zhou, Jianmin; Ma, Zhi-Yuan; Shonhe, Chantale; Ji, Su-Hui; Cai, Yun-Rui published the artcile< TEMPO-catalyzed electrochemical dehydrogenative cyclocondensation of o-aminophenols: synthesis of aminophenoxazinones as antiproliferative agents>, Synthetic Route of 40925-69-7, the main research area is aminophenol TEMPO catalyst electrochem dehydrogenative cyclocondensation green chem; aminophenoxazinone preparation antitumor SAR.
A TEMPO-catalyzed electrosynthetic method allowing the dehydrogenative cyclocondensation of o-aminophenols was reported. This mild and sustainable method proceeded in the absence of stoichiometric oxidants and used an easily available organo-electrocatalyst to access pharmaceutically valuable 2-aminophenoxazinones. Mechanistic studies indicated that the electrochem. generated TEMPO+ enables the oxidative radical homo-dimerization of o-aminophenols. The application of electrosynthesis provides an approach for the synthesis of pseudo-aminophenoxazinone alkaloids with improved structural diversification and bioactivities.
Green Chemistry published new progress about Amino phenols Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 40925-69-7 belongs to class ethers-buliding-blocks, and the molecular formula is C7H9NO2, Synthetic Route of 40925-69-7.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem