Cram, Donald J.; Tanner, Martin E.; Keipert, Steven J.; Knobler, Carolyn B. published the artcile< Host-guest complexation. 59. Two chiral [1.1.1]orthocyclophane units bridged by three biacetylene units providing a host to bind medium-sized organic guests>, Formula: C8H9BrO2, the main research area is orthocyclophane chiral preparation crystal structure; coordination dibenzotetraoxacyclodotetracontin chloroform cubane propylene oxide; crystal structure dibenzotetraoxacyclodotetracontin; host guest complexation orthocyclophane.
Title compounds I and II were prepared and complexed with CHCl3, cubane, CH2Cl, propylene oxide, Me3COH, and benzene. Thus, reaction of 4-bromo-3-methoxybenzyl alc. with P2O5-Et2O gave tribenzocyclononene III (R = Me, R1 = Br) which was methylated to give III (R1 = Me) (IV). IV was treated with BBr3 followed by HCCCH2Br to give III (R = CH2CCH, R1 = Me) (V). V reacted with Cu(OAc)2/O2 in pyridine to give I and II. The crystal structures of I and II were determined In (Cl3C)2CO as solvent the above mols. are bound by I with binding free energies that range from <4 to 5.7 kcal/mol. II failes to complex the above guests. Journal of the American Chemical Society published new progress about Coordination compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 17100-64-0 belongs to class ethers-buliding-blocks, and the molecular formula is C8H9BrO2, Formula: C8H9BrO2.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem