Jagannadham, Y.; Ramadevi, B.; Prasanna, B. published the artcile< An improved economical process for preparation of apremilast and identified their impurities>, Related Products of 608141-42-0, the main research area is acetamidophthalic acid ethoxy methoxyphenyl methylsulfonyl ethylamine cyclocondensation; apremilast preparation.
An improved and com. viable process provided for the preparation of apremilast, which was simple, cost effective and non-hazardous. The usage of acetic anhydride and high temperature was avoided. An alternative process using protected 3-aminophthalic acid with acetyl chloride in the presence of triethanolamine as catalyst in dichloromethane solvent at 0 to 5° for 1 h. then followed by condensed with (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine to get the final apremilast product was reported. Besides, there were two unknown impurities like 3-(amino-1,3-dioxoisoindolin-2-yl)phthalic acid and 4-aminoisobenzofuran-1,3-dione identified by HPLC. A thorough study was under taken to synthesize and characterize these unknown impurities. This improved process has a number of industrial advantages, such as economical material cost and relatively high yield. The structure of the synthesized compounds was elucidated by IR, 1H NMR, 13C NMR, mass spectroscopy and elemental analyses.
Asian Journal of Chemistry published new progress about Cyclocondensation reaction. 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, Related Products of 608141-42-0.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem