Kato, Eisuke; Oikawa, Kenichi; Takahashi, Keisuke; Kawabata, Jun published the artcile< Synthesis and the intestinal glucosidase inhibitory activity of 2-aminoresorcinol derivatives toward an investigation of its binding site>, Name: 2-Amino-3-methoxyphenol, the main research area is intestine glucosidase inhibitor aminoresorcinol derivative.
2-Aminoresorcinol is a potent and selective intestinal glucosidase inhibitor. Unlike the majority of glucosidase inhibitors, it shows an uncompetitive mode of inhibition. In this study, we tested the intestinal glucosidase inhibitory activity of various 2-aminoresorcinol derivatives We found that structural changes, in amino and two phenolic hydroxyl groups had a neg. impact on inhibitory activity, but methylation of the phenolic hydroxyl group was found to maintain its activity and replacement of the aromatic ring with an acyl or alkoxy carbonyl group at the 4th position also retained its activity. This enable us to design a mol. probe for further study of the inhibition mechanism of 2-aminoresorcinol.
Bioscience, Biotechnology, and Biochemistry published new progress about Carbonyl group. 40925-69-7 belongs to class ethers-buliding-blocks, and the molecular formula is C7H9NO2, Name: 2-Amino-3-methoxyphenol.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem