Wang, Bofei; Zhong, Fangrui published the artcile< Practical and Asymmetric Synthesis of Apremilast Using Ellman's Sulfinamide as a Chiral Auxiliary>, Recommanded Product: (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, the main research area is apremilast preparation enantioselective imidation.
A new protocol for the asym. synthesis of apremilast using tert-butanesulfinamide as a chiral auxiliary was described. This synthetic route consisted of four steps starting from the com. available 3-hydroxy-4-methoxybenzaldehyde and apremilast was accordingly obtained in an overall 56% yield and with 95.5% ee.
Molbank published new progress about Enantioselective synthesis. 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, Recommanded Product: (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem