Zhu, You-Quan; Hui, Li-Wen; Niu, Yun-Xia; Lv, Lin-Ge; Zhu, Kun published the artcile< Reaction of Cycloalkene-1-carboxamides with Aryl Boronates via Rhodium(III)-Catalyzed C-H Activation: A Versatile Route to 3,4-Cycloalkaquinolin-2(1H)-ones>, Quality Control of 190788-60-4, the main research area is cycloalkaquinolinone preparation; methoxycycloalkene carboxamide arylboronic acid pinacol ester heterocyclization rhodium catalyst.
Under rhodium(III) catalysis, substituted N-methoxycycloalkene-1-carboxamides I [X = CH2, O; Z = a bond, CH2; Y = CH2, N-C(O)OC(CH3)3; R1 = H, prop-1-en-2-yl] successfully reacted with aryl boronic acid pinacol esters II (R2 = 3-F, 4-C6H5O, 4-H3CO, etc.) to provide 3,4-cycloalkaquinolin-2(1H)-ones III (R3 = 9-F, 8-C6H5O, 8-H3CO, etc.) via direct functionalization of the β-alkenyl C-H bond and form C-C/C-N bond in one pot. The gram-scale synthesis of the title compound III (X = CH2; n = 1; Y = CH2; R1 = H; R3 = H) demonstrated the great synthetic utility of this methodol.
Advanced Synthesis & Catalysis published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent) (cycloalkene). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Quality Control of 190788-60-4.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem