《Synthesis and antiageing properties of antioxidant pseudopeptides designed based on the bioisostere principle》 was published in Archiv der Pharmazie (Weinheim, Germany) in 2019. These research results belong to Li, Yanbing; Zhang, Chao; Wang, Huailing; Zhou, Fan; Liu, Jie; Tang, Yinying; Jiang, Zhenlei; Liu, Zhijun; Chen, Heru. COA of Formula: C24H22N2O4 The article mentions the following:
Nineteen antioxidant pseudopeptides were designed and synthesized. They were confirmed as mild antioxidants, in which L1-11 was the most active antioxidant with a cellular antioxidant activity (CAA) value of 5.65 ± 0.64 μmol QE/g, and L1-12 was the second most active one (5.58 ± 0.66 μmol QE/g). The existence of nonnatural amino acids in L1-12 increased its stability. Pretreatment with L1-12 dose-dependently extended the lifespan of Caenorhabditis elegans. L1-12 improved resistance against UVB irradiation, oxidative stress induced by paraquat, and thermal shock. It decreased the reactive oxygen species level and upregulated the superoxide dismutase activity inside C. elegans. This pseudopeptide sensitively enhanced the expressions of the Cat-1 and Nhr-8 genes to reduce oxidative damage, leading to an extension of the lifespan. All the evidence support that L1-12 may probably be a potential antiageing agent. In the part of experimental materials, we found many familiar compounds, such as Fmoc-D-Phe(4-NH2)-OH(cas: 324017-21-2COA of Formula: C24H22N2O4)
Fmoc-D-Phe(4-NH2)-OH(cas: 324017-21-2) belongs to ethers.The C-O bonds that comprise simple ethers are strong. COA of Formula: C24H22N2O4 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem