Recommanded Product: 324017-21-2On September 20, 2021 ,《Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines》 was published in Angewandte Chemie, International Edition. The article was written by Sun, Shoujun; Gao, Bing; Chen, Junyu; Sharpless, K. Barry; Dong, Jiajia. The article contains the following contents:
Fluorosulfuryl isocyanate (FSI, FSO2NCO) is established as a reliable bis-electrophilic linker for stepwise attachment of an alc. bearing module to an amine bearing module and thence a new module RO-C(=O)-NH-SO2-NR1R2 e.g., I is created. FSI’s isocyanate motif fuses directly and quickly with alcs. and phenols, affording fluorosulfuryl carbamates in nearly quant. yield. A new reagent and process to deliver the FSI-derived fluorosulfuryl carbamate fragment to amines are also developed. The resulting SVI-F motifs from step-1 are remarkably stable, given the great structural complexities in diverse products. In the step-2 reaction with amines, the best yield of the S-N linked products arise with water alone. This “”on water”” interfacial reactivity phenomenon is crucial, revealing the latent reactivity of SVI-F probe for potential covalent capture of proteins in vivo which is important in today’s drug discovery. The scope of the SuFEx chem. is largely expanded thereby and the facile entry to these phosphate-like connections should prove useful to click chem. across diverse fields. In the part of experimental materials, we found many familiar compounds, such as Fmoc-D-Phe(4-NH2)-OH(cas: 324017-21-2Recommanded Product: 324017-21-2)
Fmoc-D-Phe(4-NH2)-OH(cas: 324017-21-2) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Recommanded Product: 324017-21-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem