Matier, W. L.; Comer, W. T.; Deitchman, D. published the artcile< Sulfamoyl azides. Hydrolysis rates and hypotensive activity>, Category: ethers-buliding-blocks, the main research area is sulfamoyl azide hypotensive; blood pressure sulfamoyl azide.
Monosubstituted sulfamoyl azides, e.g. N-(1-adamantyl)sulfamoyl azide (I) [33713-04-1] and N-(p-chlorophenyl)sulfamoyl azide (II) [13479-10-2], were significantly hypotensive in dogs at a min. ED of 0.005-0.01 mg/kg i.v., which was 1-3% of the dose required for disubstituted compounds I and II rapidly lowered blood pressure in dogs after oral administration of 1 mg/kg; the hypotensive response was apparently due to a decrease in both total peripheral resistance and aortic blood flow. The difference in hypotensive activity of mono- and disubstituted compounds appeared to be due to rapid release of azide [14343-69-2] from the former in neutral aqueous media. The mechanism and kinetics of hydrolysis were discussed. Related sulfamide derivatives were inactive. I was synthesized by reacting 1-adamantylamine with SO2Cl2 to form the sulfamoyl chloride, followed by reaction with NaN3 in dry MeCN.
Journal of Medicinal Chemistry published new progress about Antihypertensives. 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Category: ethers-buliding-blocks.
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Ether | (C2H5)2O – PubChem