Taylor, Edward C.; Andrade, Juan G.; Rall, Gerhardus J. H.; Turchi, Ignatius J.; Steliou, Kosta; Jagdmann, G. Erik Jr.; McKillop, Alexander published the artcile< Thallium in organic synthesis. 61. Intramolecular capture of radical cations from thallium(III) trifluoroacetate oxidation of arylalkanoic acids and arylalkanols. New routes to oxygen heterocycles>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is thallium trifluoroacetate oxidation arylalkenoic acid; arylalkanol thallium trifluoroacetate oxidation; cyclization oxidative arylalkanoic acid arylalkanol; coumarin dihydro; spirocyclohexadienone lactone.
Treatment of electron-rich arylpropionic acids with (F3CCO2)3Tl (I) in F3CCO2H containing a small amount of BF3 etherate gave dihydrocoumarins and spirocyclohexadienone lactones by initial formation of aromatic radical cations followed by intramol. cyclization involving the side-chain carboxyl group. The scope and limitations of this reaction with respect to aromatic substitution and the length of the alkanoic acid side chain have been examined; the reaction has been extended with analogous results to 1-naphthalenylalkanoic acids. Oxidation of a series of homologous phenyl- and naphthalenyl-1-alkanols with I under similar conditions resulted in intramol. cyclization to give fused or pendant cyclic ethers. The observed propensity for intramol. cyclization may be due to complexation of both the aryl group and the side-chain basic substituent (-CO2H or -OH) with thallium(III).
Journal of the American Chemical Society published new progress about Cyclization. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem