Han, Xing-Wang; Zhang, Tao; Yao, Wei-Wei; Chen, Hao; Ye, Mengchun published their research in CCS Chemistry in 2021. The article was titled 《Nickel- and Bronsted acid-catalyzed redox-neutral coupling of 1,3-dienes and aldehydes for synthesis of dienols》.Category: ethers-buliding-blocks The article contains the following contents:
Dienols are important structural motifs in organic mols., but most of the traditional synthetic methods required multistep prefunctionalization of substrates, leading to stoichiometric waste and low atom economy. Herein, a redox-neutral coupling of simple 1,3-dienes and aldehydes via nickel and Bronsted acid dual catalysis, providing a highly atom-economical and byproduct-free route to various dienols with up to 94% yield and up to 50:1 EE/EZ ratio is reported. The use of 2-isopropoxyphenol as a Bronsted acid co-catalyst was critical to the reactivity and selectivity. The experimental process involved the reaction of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Category: ethers-buliding-blocks)
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem