《Leveraging the Hydroarylation of α-(Trifluoromethyl)styrenes to Access Trifluoromethylated All-Carbon Quaternary Centers》 was written by Vayer, Marie; Mayer, Robert J.; Moran, Joseph; Lebœuf, David. Recommanded Product: 10365-98-7This research focused ontrifluorodiarylalkane regioselective preparation mechanism; styrene trifluoromethyl arene hydroarylation triflic acid hexafluoroisopropanol. The article conveys some information:
α-(Trifuoromethyl)styrenes are attractive olefin building blocks that have eluded hydroarylation processes. Here, the authors demonstrate that the use of a promoter system featuring triflic acid and hexafluoroisopropanol enables hydroarylation to directly build trifluoromethylated all-carbon quaternary centers. The observed reactivity significantly enriches the scope of hydroarylation of inactivated styrenes, e.g., 1-(trifluoromethyl)styrene, and provides straightforward access to trifluoromethylated diarylalkanes of interest, e.g., 1-methoxy-4-(1,1,1-trifluoro-2-phenylpropan-2-yl)benzene. Gram-scale reactions and further functionalizations illustrate the synthetic potential of this approach. In the experiment, the researchers used 3-Methoxyphenylboronic acid(cas: 10365-98-7Recommanded Product: 10365-98-7)
3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Recommanded Product: 10365-98-7
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