In 2022,Xue, Sijing; Cristofol, Alex; Limburg, Bart; Zeng, Qian; Kleij, Arjan W. published an article in ACS Catalysis. The title of the article was 《Dual Cobalt/Organophotoredox Catalysis for Diastereo- and Regioselective 1,2-Difunctionalization of 1,3-Diene Surrogates Creating Quaternary Carbon Centers》.HPLC of Formula: 60656-87-3 The author mentioned the following in the article:
The synthesis of quaternary carbons RCH(OH)C(R1)(Me)CH=CH2(R = Ph, naphthalen-2-yl, 4-(prop-1-en-2-yl)cyclohex-1-en-1-yl, furan-2-yl, etc.; R1 = Ph, 4-MeOPh, 4-MePh, 4F-Ph, 4-Cl-Ph, etc.) through a catalytic stereo- and regioselective difunctionalization of 2-substituted 1,3-dienes C6H5CH(OH)C(C6H5)(CH2R2)CH=CH2 remains elusive. Here, a dual Co/photoredox-catalyzed cascade approach that addresses this challenge using modular vinyl cyclic carbonates functioning as masked 2-aryl-1,3-dienes I surrogates was presented. The latter species are conveniently prepared in situ and converted into nucleophilic Co(allyl) intermediates that are intercepted by aldehydes to afford homoallylic alcs. compound (I) with ample scope in reaction partners. The developed protocol marks a significant step forward in the use of structurally versatile 1,3-dienes I and their catalytic 1,2-hydroalkylation and 1,2-dicarbofunctionalization. In the experimental materials used by the author, we found 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3HPLC of Formula: 60656-87-3)
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).HPLC of Formula: 60656-87-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem