On September 6, 2021, Kang, Qi-Kai; Lin, Yunzhi; Li, Yuntong; Xu, Lun; Li, Ke; Shi, Hang published an article.Quality Control of 2-Methylanisole The title of the article was Catalytic SNAr Hydroxylation and Alkoxylation of Aryl Fluorides. And the article contained the following:
A reliable method for accessing phenols ArOH (Ar = C6H5, 4-CH3OC6H4, 9H-fluoren-2-yl, etc.) and Ph alkyl ethers Ar1OR (Ar1 = 4-CH3C6H4, 9H-fluoren-2-yl, 1-methyl-2-oxo-2,3-dihydro-1H-indol-5-yl, etc.; R = Me, cyclohexylmethyl, oxan-4-yl, etc.) via catalytic SnAr reactions has been described. The method is applicable to a broad array of electron-rich and neutral aryl fluorides ArF and Ar1F, which are inert under classical SnAr conditions. Although the mechanism of SNAr reactions involving metal arene complexes is hypothesized to involve a stepwise pathway (addition followed by elimination), exptl. data that support this hypothesis is still under exploration. Mechanistic studies and DFT calculations suggest either a stepwise or stepwise-like energy profile. Notably, a rhodium η5-cyclohexadienyl complex intermediate with an sp3-hybridized carbon bearing both a nucleophile and a leaving group was isolated. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Quality Control of 2-Methylanisole
The Article related to phenol preparation dft mechanistic study, water aryl fluoride hydroxylation rhodium catalyst, ester preparation dft mechanistic study, aryl fluoride alc alkoxylation rhodium catalyst, c−o bond formation, meisenheimer-type intermediate, rhodium, η6-coordination and other aspects.Quality Control of 2-Methylanisole
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem