On June 17, 2010, Chen, Li; Feng, Lichun; Yang, Minmin; Dillon, Michael Patrick; Lai, Yingjie published a patent.Application In Synthesis of (S)-1-Methoxypropan-2-amine hydrochloride The title of the patent was Preparation of thiadiazole-substituted arylamides as P2X3 and P2X2/3 antagonists for treatment of pain and urinary tract disease. And the patent contained the following:
Compounds of the formula I (wherein R1 is (un)substituted thiadiazolyl; R2 is (un)substituted Ph, (un)substituted pyridinyl, (un)substituted pyrimidinyl, etc.; R3 is H, C1-6alkyl, or CN; R4 is H or C1-6alkyl; or R3 and R4 together with the atom to which they are attached may form a C3-6 carbocyclic ring; R5 is C1-6alkyl, C1-6alkoxy-C1-6alkyl, hydroxy-C1-6alkyl, etc.; or R4 and R5 together form part of a ring; or R3, R4, and R5 together form part of ring; R6, R7 and R8 are independently H, C1-6alkyl, C1-6alkyloxy, etc.) or a pharmaceutically acceptable salt thereof, are disclosed. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptors and methods of making the compounds Example compound II, prepared in a multistep reaction that culminated in the reaction of 3-(4-isopropyl-[1,2,3]thiadiazol-5-yl)-5-(5-methylpyridin-2-yl)benzoic acid and C-(5-methylpyrazin-2-yl)methylamine, had pKi values of 8.04 and 7.43 for P2X3 and P2X2/3 receptors, resp. The experimental process involved the reaction of (S)-1-Methoxypropan-2-amine hydrochloride(cas: 1162054-86-5).Application In Synthesis of (S)-1-Methoxypropan-2-amine hydrochloride
The Article related to thiadiazole arylamide preparation p2x3 p2x2 antagonist pain urinary disease, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of (S)-1-Methoxypropan-2-amine hydrochloride
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem