On November 19, 1992, Achard, Daniel; Grisoni, Serge; Hanessian, Stephen; Moutonnier, Claude; Peyronel, Jean Francois; Tabart, Michel; Truchon, Alain published a patent.Quality Control of (S)-2-(2-Methoxyphenyl)propanoic acid The title of the patent was Perhydroisoindoles, their preparation and pharmaceutical compositions containing them as substance P antagonists. And the patent contained the following:
Perhydroisoindole derivatives I [R = H or form a bond; R5 = 2- or 3-halo- or Me-substituted Ph; Z = O, NH; R1 = (un)substituted Ph, cyclohexadienyl, naphthyl, heterocyclyl; R2 = H, halo, OH, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxy, alkylthio, acyloxy, carboxy, (un)substituted alkoxycarbonyl, benzyloxycarbonyl, amino, acylamino; R3 = halide, OH; R4 = H, or halo if R3 = halo] and their salts, prepared by reaction of R1CHR2CO2H or R1CHR2CR6:NH (R6 = C1-4 alkoxy, MeS, EtS, PhCH2S, alkoxycarbonylmethylthio) with the corresponding perhydroisoindoles, are claimed. The preparation of isomers of I, mixtures of isomers, and their salts are claimed. The compounds are particularly interesting as substance P antagonists; tests of 3 compounds, and 29 synthetic examples are described. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Quality Control of (S)-2-(2-Methoxyphenyl)propanoic acid
The Article related to perhydroisoindole preparation substance p antagonist, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of (S)-2-(2-Methoxyphenyl)propanoic acid
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem