Washington, Jack B.; Assante, Michele; Yan, Chunhui; McKinney, David; Juba, Vanessa; Leach, Andrew G.; Baillie, Sharon E.; Reid, Marc published an article in 2021, the title of the article was Trialkylammonium salt degradation: implications for methylation and cross-coupling.Recommanded Product: 2-Methylanisole And the article contains the following content:
This study presented a mechanistic degradation anal. of N,N,N-trimethylanilinium salts and highlighted implications for synthetic applications of this important class of salts. Kinetic degradation studies, in both solid and solution phases, had delivered insights into phys. and chem. parameters affecting anilinium salt stability. 1H NMR kinetic anal. of salt degradation had evidenced thermal degradation to Me iodide and parent aniline, consistent with a closed-shell SN2-centered degradative pathway, and Me iodide being key reactive species in applied methylation procedures. Furthermore, effect of halide and non-nucleophilic counterions on salt degradation had been investigated, along with deuterium isotope and solvent effects. New mechanistic insights had enabled investigation of use of trimethylanilinium salts in O-methylation and in improved cross-coupling strategies. Finally, detailed computational studies had helped highlight limitations in current state-of-the-art of solvation modeling of reaction in which bulk medium undergoes exptl. observable changes over reaction timecourse. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Recommanded Product: 2-Methylanisole
The Article related to trialkylammonium salt preparation degradation reaction mechanism dft, methoxy hydrocarbon preparation, alc acid phenol trimethylanilinium salt methylation, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 2-Methylanisole
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