Beni, Ryan; Boadi, William; Karim, Kaleh; Alnakhli, Jawzah; Alhamed, Samiyah published an article in 2019, the title of the article was Synthesis and antiproliferative activities of triphenylmethanol conjugates of leuprorelin.SDS of cas: 321-28-8 And the article contains the following content:
Leuprorelin (LEP) is an FDA drug for breast cancer and prostate cancer treatment. There are several reported adverse effects such as transient hypertension, excessive salivation, and increased dysuria during treatment with LEP. In this study, the efficacy and toxicity of LEP were modified by using a drug delivery system to adjust the physicochem. properties. In this regard, Leuprorelin conjugates of triphenylmethanol derivatives (TPMs) were synthesized as prodrugs. Comparative antiproliferative assays showed that LEP-TPMs conjugates had significantly higher antiproliferative activities than the corresponding non-covalent phys. mixtures of the TPMs and LEP against human invasive ductal carcinoma (BT549), human prostate carcinoma (PC3), human lung cancer (A549) and mouse pre-adipocytes (3T3-L1) cells. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).SDS of cas: 321-28-8
The Article related to leuprorelin triphenylmethanol conjugate antiproliferative invasive ductal prostate carcinoma adipocyte, Placeholder for records without volume info and other aspects.SDS of cas: 321-28-8
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem