On January 25, 2021, Gisbert-Alonso, A.; Navarro-Huerta, J. A.; Torres-Lapasio, J. R.; Garcia-Alvarez-Coque, M. C. published an article.Synthetic Route of 578-58-5 The title of the article was Global retention models and their application to the prediction of chromatographic fingerprints. And the article contained the following:
The resolution of samples containing unknown compounds of different nature, or without standards available, as is the case of chromatog. fingerprints, is still a challenge. Possibly, the most problematic aspect that prevents systematic method development is finding models that describe without bias the retention behavior of the compounds in the samples. In this work, the use of global models (able to describe the whole sample) is proposed as an alternative to the use of individual models for each solute. Global models contain parameters that are specific for each solute, while other parameters -related to the column and solvent- are common for all solutes. A special regression procedure is presented for the construction of global models, which are applied to predict highly complex chromatograms, such as chromatog. fingerprints, for diverse exptl. conditions in isocratic and gradient elution. Another interesting application is the prediction of mol. properties, such as log Po/w, from the specific solute parameters of the global models. The examined adapted models are based on the equations proposed by Snyder, Schoenmakers, Neue and Kuss, Jandera, and Bosch Roseś to describe the retention. In all cases, the predictive capability was very satisfactory. Two cases of study were considered: chromatograms of chamomile extracts analyzed using acetonitrile gradients, and a set of 145 known compounds in a wide range of structures and functionalities, eluted isocratically with acetonitrile/water mobile phases. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Synthetic Route of 578-58-5
The Article related to global retention model chromatog fingerprints, global retention models, gradient elution, hplc, medicinal plants, prediction of chromatographic fingerprints, Organic Analytical Chemistry: Separations and other aspects.Synthetic Route of 578-58-5
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