Teng, Kun-Xu; Niu, Li-Ya; Yang, Qing-Zheng published an article in 2022, the title of the article was A host-guest strategy for converting the photodynamic agents from a singlet oxygen generator to a superoxide radical generator.Category: ethers-buliding-blocks And the article contains the following content:
Type-I photosensitizers (PSs) generate cytotoxic oxygen radicals by electron transfer even in a hypoxic environment. Nevertheless, the preparation of type-I PSs remains a challenge due to the competition of triplet-triplet energy transfer with O2 (type-II process). In this work, we report an effective strategy for converting the conventional type-II PS to a type-I PS by host-guest complexation. Electron-rich pillar[5]arenes are used as an electron donor and macrocyclic host to produce a host-guest complex with the traditional electron-deficient type-II PS, an iodide BODIPY-based guest. The host-guest complexation promotes intermol. electron transfer from the pillar[5]arene moiety to BODIPY and then to O2 by the type-I process upon light-irradiation, leading to efficient generation of the superoxide radical (O2- ). The results of anti-tumor studies indicate that this supramol. PS demonstrates high photodynamic therapy efficacy even under hypoxic conditions. This work provides an efficient method to prepare type-I PSs from existing type-II PSs by using a supramol. strategy. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Category: ethers-buliding-blocks
The Article related to hypoxia photodynamics oxygen type ii photosensitizer glassy carbon electrode, Placeholder for records without volume info and other aspects.Category: ethers-buliding-blocks
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Ether | (C2H5)2O – PubChem