Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (Part-II) was written by Sessions, E. Hampton;Chowdhury, Sarwat;Yin, Yan;Pocas, Jennifer R.;Grant, Wayne;Schroeter, Thomas;Lin, Li;Ruiz, Claudia;Cameron, Michael D.;LoGrasso, Philip;Bannister, Thomas D.;Feng, Yangbo. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Application In Synthesis of N-(3-Methoxybenzyl)ethanamine The following contents are mentioned in the article:
Therapeutic interventions with Rho kinase (ROCK) inhibitors may effectively treat several disorders such as hypertension, stroke, cancer, and glaucoma. Herein we disclose the optimization and biol. evaluation of potent novel ROCK inhibitors based on substituted indole and 7-azaindole core scaffolds, e.g. I, II and III (X = N, CH). Substitutions on the indole C3 position and on the indole NH and/or amide NH positions all yielded potent and selective ROCK inhibitors. Improvement of aqueous solubility and tailoring of in vitro and in vivo DMPK properties could be achieved through these substitutions. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3Application In Synthesis of N-(3-Methoxybenzyl)ethanamine).
N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application In Synthesis of N-(3-Methoxybenzyl)ethanamine
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem