Shedding light on curcumin stability was written by Appendino, Giovanni;Allegrini, Pietro;de Combarieu, Eric;Novicelli, Federico;Ramaschi, Giuseppe;Sardone, Nicola. And the article was included in Fitoterapia in 2022.Synthetic Route of C19H16O4 The following contents are mentioned in the article:
The stability of mol. curcumin (purcumin, 1a) in solution is strongly light-dependent. Under laboratory artificial light, a relative stability is observed only at neutral pH, while more intense light and/or solar light can trigger degradation via a combination of hydrolytic and oxidative fragmentation of the heptadiendione moiety. Minor curcuminoids in com. curcumin (purcuminoids) can improve the stability of mol. curcumin, but only under conditions of low irradiation While confirming earlier observations alerting to the instability of purcumin, our results provide new rationales for unexplained differences between previous studies, question the biol. relevance of a non-enzymic degradation for the bioactivity profiles that have been reported for purcumin, and highlight the need of a better characterization of the degradation of purcuminoids under visible light irradiation This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Synthetic Route of C19H16O4).
Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Synthetic Route of C19H16O4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem