Merey, Hanan A. published the artcileSimultaneous determination of pramocaine HCl and hydrocortisone acetate in pharmaceutical dosage form, Category: ethers-buliding-blocks, the publication is Journal of Liquid Chromatography & Related Technologies (2013), 36(19), 2774-2784, database is CAplus.
Two sensitive and selective methods were developed and validated for simultaneous determination of pramocaine HCl and hydrocortisone acetate in pharmaceutical dosage form. The first method is a spectrodensitometric method where pramocaine HCl and hydrocortisone acetate were separated using toluene:methanol:chloroform: 10% NH3 [(5:3:6:0.1, by volume) as the developing system followed by densitometric measurement at 290 nm] and 250 nm for pramocaine HCl and hydrocortisone acetate, resp. The second method is a high performance liquid chromatog. method for separation and determination of both drugs using reversed phase C18 column and mobile phase consisting of distilled water:acetonitrile:triethylamine (530:470:0.1, by volume); pH was adjusted to 3 by o-phosphoric acid. The proposed methods were successfully applied for the anal. of pramocaine HCl and hydrocortisone acetate in laboratory prepared mixtures and in pharmaceutical dosage form and the results obtained were assessed by applying the standard addition technique. Statistical comparison between the results obtained by applying the proposed methods and official method for the cited drugs was done and no significant difference was found at p = 0.05.
Journal of Liquid Chromatography & Related Technologies published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Category: ethers-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Ether,
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