Jirousek, Ludek’s team published research in Journal of Pharmacology and Experimental Therapeutics in 191 | CAS: 14807-75-1

Journal of Pharmacology and Experimental Therapeutics published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Category: ethers-buliding-blocks.

Jirousek, Ludek published the artcilePositive iodine compounds as models of the thyroidal active iodine. Reaction of N-iodosuccinimide and of N-iodophthalimide with thiocarbamide goitrogens, Category: ethers-buliding-blocks, the publication is Journal of Pharmacology and Experimental Therapeutics (1974), 191(2), 341-8, database is CAplus and MEDLINE.

N-iodosuccinimide (I) [516-12-1] and N-iodophthalimide (II) [20919-42-0] reacted with 37 goitrogenic thiocarbamides in dimethyl sulfoxide to form thiocarbamide sulfenyl iodide derivatives as reaction intermediates; nongoitrogenic carbamides and other chem. analogs were unreactive. Structural studies indicated an influence of mesomerisms in the thiocarbamides on the overall reaction pathway. Some potent goitrogens were not oxidized beyond the disulfide stage. Behavior of the N-iodoimides imitates that of thyroidal active iodine more closely than I2 does, suggesting that trapping of pos. iodine is more important than the possible subsequent redox reactions in the mechanism of drug goitrogenicity.

Journal of Pharmacology and Experimental Therapeutics published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem