Khan, Jabir published the artcileLambert Salt-Initiated Development of Friedel-Crafts Reaction on Isatin to Access Distinct Derivatives of Oxindoles, Name: 1,2-Dimethoxybenzene, the publication is Journal of Organic Chemistry (2021), 86(24), 17833-17847, database is CAplus and MEDLINE.
Herein, a mild metal-free and efficacious route for the synthesis of biol. important 3-aryl oxindole derivatives I [R = H, OH, 4-MeOC6H4, etc.; R1 = H, Me, Br, etc.; R2 = H, NO2, Cl; R3 = H, Me, Bn, Ts; Ar = 4-HOC6H4, 2,4,6-tri-MeOC6H2, 1H-indol-3-yl, etc.] was described. Using Lambert salt-initiated hydroarylation of isatin, a diverse array of monoarylated products, sym./unsym. double-arylated products and deoxygenated hydroarylated products could be synthesized from the single starting substrate in good to excellent yields. A preliminary mechanistic study revealed that the reaction proceeded via a monoarylated product followed by a nucleophilic attack by another electron-rich arene nucleophile under mild conditions. The potential of newly synthesized sym./unsym. 3,3-disubstituted oxindole, 3-substituted 3-hydroxy oxindoles, 3,3-di(indolyl)indolin-2-ones, and α-aryl oxindoles as valuable building blocks was further illustrated.
Journal of Organic Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,2-Dimethoxybenzene.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem