Taguchi, Hiroyasu published the artcileSynthesis and Tautomerism of Curcumin Derivatives and Related Compounds, Safety of 2-(2,2,2-Trifluoroethoxy)ethanol, the publication is Australian Journal of Chemistry (2015), 68(2), 224-229, database is CAplus.
1,7-Bis(4′-hydroxy-3′-trifluoromethoxyphenyl)-1,6-heptadiene-3,5-dione, related to curcumin, and thirteen 4-substituted derivatives were prepared and their keto/enol ratio in DMSO[D6] was determined by 19F NMR because the enolic form of these related curcumins had been shown to bind to amyloid plaques in the Alzheimer brain. The parent compound and the 4-ethoxycarbonyl derivative were almost 100% in the enolic form that contains a conjugated hepta-1,4,6-trien-3-on-5-ol backbone. Enolisation decreased to varying amounts in the derivatives that had 4-substituted alkyl groups. Attempts to prepare the 4-hydroxypropyl derivative by hydrolysis of O-methoxymethyl or O-tetrahydropyranyloxy protected derivatives led to cyclised products. A related pyrimidine compound that mimicked a fixed enol form was also prepared
Australian Journal of Chemistry published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C5H5BrN2, Safety of 2-(2,2,2-Trifluoroethoxy)ethanol.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem