Wagner, Eva published the artcileMepyramine-JNJ7777120-hybrid compounds show high affinity to hH1R, but low affinity to hH4R, Computed Properties of 52818-63-0, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(21), 6274-6280, database is CAplus and MEDLINE.
In literature, a synergism between histamine H1 and H4 receptor is discussed. Furthermore, it was shown, that the combined application of mepyramine, a H1 antagonist and JNJ7777120, a H4 receptor ligand leads to a synergistic effect in the acute murine asthma model. Thus, the aim of this study was to develop new hybrid ligands, containing one H1 and one H4 pharmacophore, connected by an appropriate spacer, in order to address both, H1R and H4R. Within this study, we synthesized nine hybrid compounds, which were pharmacol. characterized at hH1R and hH4R. The new compounds revealed (high) affinity to hH1R, but showed only low affinity to hH4R. Addnl., we performed mol. dynamic studies for some selected compounds at hH1R, in order to obtain information about the binding mode of these compounds on mol. level.
Bioorganic & Medicinal Chemistry Letters published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H18BClO3, Computed Properties of 52818-63-0.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem