Wu, Jing published the artcileDiscovery of novel paeonol-based derivatives against skin inflammation in vitro and in vivo, COA of Formula: C8H11NO, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2022), 37(1), 817-831, database is CAplus and MEDLINE.
In this study, a series of paeonol derivatives I [R = NHMe, PhNH, BnNH, etc.] was designed and synthesized using a fragment growing approach, and their anti-inflammatory activities against lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 cells were tested. Among them, compound I [R = 3-CF3C6H4NH] yielded the best results (IC50 = 2.14μM) with low toxicity (IC50 > 50μM). Preliminary mechanistic studies indicated that this compound could inhibit the TOPK-p38/JNK signalling pathway and phosphorylate downstream related proteins. A murine psoriasis-like skin inflammation model was used to determine its therapeutic effect.
Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem