Schmidt, Andrea C. published the artcileThe Role of Molecular Structure in the Crystal Polymorphism of Local Anesthetic Drugs: Crystal Polymorphism of Local Anesthetic Drugs, Part X, Recommanded Product: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Pharmaceutical Research (2005), 22(12), 2121-2133, database is CAplus and MEDLINE.
This report is the resume of a comprehensive investigation on the solid-state properties and the crystal polymorphism of the structurally homogeneous class of local anesthetic drugs. The goal is to explore the relationship between crystal polymorphism and mol. structural features. A salt form (mostly the hydrochloride) as well as the free base of 24 local anesthetics has been characterized by means of thermomicroscopy, differential scanning calorimetry, pycnometry, Fourier transform IR, Fourier transform Raman, and solid-state NMR spectroscopies, as well as x-ray diffraction methods (single crystal, powder). Based on the thermochem. data, the relative thermodn. stabilities of the different crystal forms of each polymorphic system were evaluated and visualized as semiquant. energy/temperature diagrams. This study is the first step in recognizing relationships between the structure and the solid-state properties within this limited group of active substances with common structural elements. The results clearly show that there are certain relationships, but, to understand the phenomenol. behavior in more detail on a mol. level, more structural information must be collected and analyzed by computational methods.
Pharmaceutical Research published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Recommanded Product: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem