QSAR analysis of the antiherpetic activity of macroheterocyclic compounds and their structural analogs was written by Artemenko, A. G.;Liahovskiy, A. V.;Muratov, E. N.;Basok, S. S.;Lozitsky, V. P.;Fedchuk, A. S.;Gridina, T. V.;Kuz’min, V. E.. And the article was included in Dopovidi Natsional’noi Akademii Nauk Ukraini in 2010.Formula: C10H21NO4 This article mentions the following:
The anal. of the structure-antiherpetic activity relationship for nitroqen-containing cyclic compounds with the usage of QSAR methods on the basis of the simplex representation of a mol. structure and the circular model has been carried out. Structural factors which are responsible for the antiherpetic activity realization are determined on the basis of the interpretation of the developed adequate models. Several highly active compounds have been designed on the basis of this information. The high antiherpetic activity for three of them is confirmed exptl. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Formula: C10H21NO4).
1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Formula: C10H21NO4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem