Identification of an Oxalamide Ligand for Copper-Catalyzed C-O Couplings from a Pharmaceutical Compound Library was written by Chan, Vincent S.;Krabbe, Scott W.;Li, Changfeng;Sun, Lijie;Liu, Yue;Nett, Alex J.. And the article was included in ChemCatChem in 2019.SDS of cas: 54916-28-8 This article mentions the following:
The use of pharmaceutical compound library approach in combination with high throughput screening to identify N,N’-bis(thiophene-2-ylmethyl)oxalamide as a ligand that was generally effective for copper-catalyzed C-O cross-couplings to prepare both biarylethers as well as phenols under mild conditions. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8SDS of cas: 54916-28-8).
1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.SDS of cas: 54916-28-8
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem