N-Arylation of Sterically Hindered NH-Nucleophiles: Copper-Mediated Syntheses of Diverse N-Arylindole-2-carboxylates was written by Lee, Jinyong;Choi, Ji Hye;Shin, Seunghoon;Heo, Jung-Nyoung;Lim, Hwan Jung. And the article was included in Synthesis in 2015.Computed Properties of C7H5BrF2O This article mentions the following:
Indole-carboxylates are N-arylated with 2-bromopyridines using stoichiometric copper(II) oxide/potassium carbonate to give various N-(2-pyridyl)-substituted indole-2-carboxylates e. g., I, and with bromobenzenes using stoichiometric copper(I) iodide/N,N’-dimethylethylenediamine to give various N-(substituted phenyl)-substituted indole-2-carboxylates, e. g., II. These results expand the scope of metal-catalyzed N-arylation using heterocyclic amines with steric bulk and weak nucleophilicity. In the experiment, the researchers used many compounds, for example, 4-Bromo-2,6-difluoroanisole (cas: 104197-14-0Computed Properties of C7H5BrF2O).
4-Bromo-2,6-difluoroanisole (cas: 104197-14-0) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Computed Properties of C7H5BrF2O
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem