Ritter, Janet D. Sharp et al. published their research in Journal of the American Chemical Society in 1964 | CAS: 6972-61-8

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Category: ethers-buliding-blocks

ρ-ρ Relation and the reaction of trans-cinnamic acids with diphenyldiazomethane. Basis of the Hammett equation was written by Ritter, Janet D. Sharp;Miller, Sidney I.. And the article was included in Journal of the American Chemical Society in 1964.Category: ethers-buliding-blocks This article mentions the following:

Rate data for the reactions of 15 trans-cinnamic acids [2m-AcO, mCl, p-Cl, H, m-F, p-F, p-OH, p-iso-Pr, m-MeO, p-MeO, p-Me, m-NO2, p-NO2, p-Me2N, and 2,4-(MeO)2] with diphenyldiazomethane (DDM) in EtOH have been obtained. The entropies of activation (-ΔS* = 8-21 e.u.) are proportional to the activation energies (Eact = 12-17 kcal. mole-1) in this series with a slope of ∼298°. Satisfactory Hammett lines for 12 substituents have been obtained: at 25° with k in 1. mole-1 min.-1, log k = 0.41 σ – 0.1705; at 35°, log k = 0.43 σ + 0.1757. The ρ-value for the cinnamic acids follows the relation, ρRGCO2H÷ρRGCOS = constant, suggesting that the factors affecting the transmission of electronic effects in acid dissociation parallel those in the reactions of the acids with DDM. For systems of the type RGCO2H, the link between ρ and the distance across G, the polarizability of G, or σ-values involving G are discussed. In some cases, field and mesomeric-inductive effects as embodied in the Kirkwood-Westheimer and Dewar-Grisdale theories can generate observed rate or equilibrium properties. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Category: ethers-buliding-blocks).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem